What is the difference between Paddle and Basket ? Why we are using Basket or paddle in dissolution ?



What is the difference between Paddle and Basket ? Why we are using Basket or paddle in dissolution ?

  • Paddle and baskets are the different type of the apparatus used in dissolution to find the drug release.
  • Generally, baskets are used for capsule or ur tablet flotting in media. paddle can be used for all.
  • Some times paddle is also used in the capsule and flotting tablets by using sinker to achieve appropriate result.

Paddle Dissolution Method:

  • In this method, the rotating shaft is fixed to a blade attached vertically at the end.
  • This blade is meant to act as a stirrer to mix the drug being tested with the liquid inside the holding vessel.
  • Typically, the drug is placed inside the holding vessel and once it settles at the bottom, the rotating shaft is switched on to begin mixing.
  • The drug being tested is also frequently attached to a sinker to prevent the drug from attaching itself to the vessel walls and also to ensure the drug being tested remains positioned beneath the rotating shaft.
  • This sinker is made from a non-reactive element to prevent it from reacting with the drug sample it holds.
Paddle and Basket Dissolution Method

Paddle and Basket Dissolution Method

Basket Dissolution Method

  • In the basket dissolution method, a different apparatus is placed at the end of the rotating shaft. This apparatus is called a basket.
  • It is cylindrical in shape and is constructed from non-reactive mesh to prevent any unwanted chemical reactions that may alter the final result.
  • The pores in the mesh allow the dissolving drug to move from the basket into the holding vessel, creating a uniform solution.
  • The drug being tested is first placed inside the basket that is firmly attached to the end of the rotating shaft.
  • Once the drug is securely in place, the motor is switched on and the shaft begins rotating the basket inside the vessel.
  • The sticky tablets containing HPMC or similar compounds as a binder are tested using a basket because tablet swells in water and may stick to the walls of the dissolution vessel.

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