What is the difference between Paddle and Basket ? Why we are using Basket or paddle in dissolution ?

webmaster — Sat, 03 Jul 2021 12:14:56 +0000

Paddle and baskets are the different type of the apparatus used in dissolution to find the drug release.
Generally, baskets are used for capsule or ur tablet flotting in media. paddle can be used for all.
Some times paddle is also used in the capsule and flotting tablets by using sinker to achieve appropriate result.

Paddle Dissolution Method:

In this method, the rotating shaft is fixed to a blade attached vertically at the end.
This blade is meant to act as a stirrer to mix the drug being tested with the liquid inside the holding vessel.
Typically, the drug is placed inside the holding vessel and once it settles at the bottom, the rotating shaft is switched on to begin mixing.
The drug being tested is also frequently attached to a sinker to prevent the drug from attaching itself to the vessel walls and also to ensure the drug being tested remains positioned beneath the rotating shaft.
This sinker is made from a non-reactive element to prevent it from reacting with the drug sample it holds.

In the basket dissolution method, a different apparatus is placed at the end of the rotating shaft. This apparatus is called a basket.
It is cylindrical in shape and is constructed from non-reactive mesh to prevent any unwanted chemical reactions that may alter the final result.
The pores in the mesh allow the dissolving drug to move from the basket into the holding vessel, creating a uniform solution.
The drug being tested is first placed inside the basket that is firmly attached to the end of the rotating shaft.
Once the drug is securely in place, the motor is switched on and the shaft begins rotating the basket inside the vessel.
The sticky tablets containing HPMC or similar compounds as a binder are tested using a basket because tablet swells in water and may stick to the walls of the dissolution vessel.