{"id":29,"date":"2021-07-03T12:14:56","date_gmt":"2021-07-03T12:14:56","guid":{"rendered":"https:\/\/www.wikitechy.com\/interview-questions\/?p=29"},"modified":"2021-09-15T06:37:55","modified_gmt":"2021-09-15T06:37:55","slug":"what-is-the-difference-between-paddle-and-basket-why-we-are-using-basket-or-paddle-in-dissolution","status":"publish","type":"post","link":"https:\/\/www.wikitechy.com\/interview-questions\/chemistry-interview-questions\/what-is-the-difference-between-paddle-and-basket-why-we-are-using-basket-or-paddle-in-dissolution\/","title":{"rendered":"What is the difference between Paddle and Basket ? Why we are using Basket or paddle in dissolution ?"},"content":{"rendered":"\r\n<ul class=\"wp-block-list\" style=\"text-align: justify;\">\r\n<li>Paddle and baskets are the different type of the apparatus used in dissolution to find the drug release.<\/li>\r\n<li>Generally, baskets are used for capsule or ur tablet flotting in media. paddle can be used for all.<\/li>\r\n<li>Some times paddle is also used in the capsule and flotting tablets by using sinker to achieve appropriate result.<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<h2 id=\"paddle-dissolution-method\" class=\"wp-block-heading\" style=\"text-align: justify;\">Paddle Dissolution Method:<\/h2>\r\n\r\n\r\n\r\n<ul class=\"wp-block-list\" style=\"text-align: justify;\">\r\n<li>In this method, the rotating shaft is fixed to a blade attached vertically at the end.<\/li>\r\n<li>This blade is meant to act as a stirrer to mix the drug being tested with the liquid inside the holding vessel.<\/li>\r\n<li>Typically, the drug is placed inside the holding vessel and once it settles at the bottom, the rotating shaft is switched on to begin mixing.<\/li>\r\n<li>The drug being tested is also frequently attached to a sinker to prevent the drug from attaching itself to the vessel walls and also to ensure the drug being tested remains positioned beneath the rotating shaft.<\/li>\r\n<li>This sinker is made from a non-reactive element to prevent it from reacting with the drug sample it holds.<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<figure class=\"wp-block-image\" style=\"text-align: justify;\"><\/figure>\r\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-medium\" src=\"https:\/\/cdn.wikitechy.com\/interview-questions\/Chemistry\/paddle-basket.png\" alt=\"paddle basket\" width=\"280\" height=\"240\" \/><\/p>\r\n\r\n\r\n\r\n\r\n\r\n<h2 id=\"basket-dissolution-method\" class=\"wp-block-heading\" style=\"text-align: justify;\">Basket Dissolution Method<\/h2>\r\n\r\n\r\n\r\n<ul class=\"wp-block-list\" style=\"text-align: justify;\">\r\n<li>In the basket dissolution method, a different apparatus is placed at the end of the rotating shaft. This apparatus is called a basket.<\/li>\r\n<li>It is cylindrical in shape and is constructed from non-reactive mesh to prevent any unwanted chemical reactions that may alter the final result.<\/li>\r\n<li>The pores in the mesh allow the dissolving drug to move from the basket into the holding vessel, creating a uniform solution.<\/li>\r\n<li>The drug being tested is first placed inside the basket that is firmly attached to the end of the rotating shaft.<\/li>\r\n<li>Once the drug is securely in place, the motor is switched on and the shaft begins rotating the basket inside the vessel.<\/li>\r\n<li>The sticky tablets containing HPMC or similar compounds as a binder are tested using a basket because tablet swells in water and may stick to the walls of the dissolution vessel.<\/li>\r\n<\/ul>\r\n","protected":false},"excerpt":{"rendered":"<p>Answer : Paddle and baskets are the different type of the apparatus&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3,9601,9599,9602,9583,9595,9600,9585,9592,9604,4,9594,9587,9591,9596,9598,9593,9605,9603,9597,15877],"class_list":["post-29","post","type-post","status-publish","format-standard","hentry","category-chemistry-interview-questions","tag-apollo-paints-interview-questions","tag-basket-apparatus","tag-basket-dissolution-apparatus","tag-basket-method","tag-basket-type-dissolution-apparatus","tag-difference-between-paddle-and-basket-in-dissolution","tag-dissolution-basket","tag-dissolution-basket-mesh-size","tag-dissolution-paddle","tag-dissolving-basket","tag-gem-paints-interview-questions","tag-paddle-apparatus","tag-paddle-dissolution-apparatus","tag-paddle-method","tag-paddle-method-dissolution-test","tag-paddle-over-disk","tag-paddle-over-disk-dissolution-apparatus","tag-rotating-basket-apparatus","tag-rotating-basket-method","tag-usp-paddle-method","tag-zydus-cadila-interview-questions-and-answers"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is the difference between Paddle and Basket ? - Chemistry<\/title>\n<meta name=\"description\" content=\"What is the difference between Paddle and Basket ? 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